Nanoemulsion formulation for enhancing the aqueous solubility and systemic bioavailability of poorly soluble drugs.
نویسندگان
چکیده
منابع مشابه
Pharmaceutical Technologies for Enhancing Oral Bioavailability of Poorly Soluble Drugs
The oral bioavailability of BCS (biopharmaceutics classification system) class II drugs with poor solubility and reasonable permeability is limited by the drug dissolution step from drug products. Though prodrug approach is an exciting way of improving the oral bioavailability, it requires extensive studies to establish the safety profile of prodrugs in humans. In view of the increasing market ...
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The objective of this study was to develop nanoemulsion formulations for enhancement of oral bioavailability of paclitaxel, a model hydrophobic drug and P-glycoprotein substrate. The oil-in-water (o/w) nanoemulsions were made with pine nut oil as the internal oil phase, egg lecithin as the primary emulsifier, and water as the external phase. Stearylamine and deoxycholic acid were used to impart...
متن کاملTechnologies to Improve the Solubility, Dissolution and Bioavailability of Poorly Soluble Drugs
Submit Manuscript | http://medcraveonline.com based formulations are filled into hard or soft gelatin capsules. Drugcyclodextrin inclusion complexes are generally prepared by Coprecipitate and Spray drying methods. A number of poorly soluble drugs have been successfully introduced to the market by using new technologies. Among the available technologies, solid dispersion formulations and lipid ...
متن کاملTechnologies to Improve the Solubility, Dissolution and Bioavailability of Poorly Soluble Drugs
Submit Manuscript | http://medcraveonline.com based formulations are filled into hard or soft gelatin capsules. Drugcyclodextrin inclusion complexes are generally prepared by Coprecipitate and Spray drying methods. A number of poorly soluble drugs have been successfully introduced to the market by using new technologies. Among the available technologies, solid dispersion formulations and lipid ...
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ژورنال
عنوان ژورنال: Records of Pharmaceutical and Biomedical Sciences
سال: 2023
ISSN: ['2535-2091', '2536-9857']
DOI: https://doi.org/10.21608/rpbs.2023.203561.1221